P-glycoprotein Expression and Pharmacoresistant Epilepsy: Cause or Consequence?
نویسندگان
چکیده
منابع مشابه
P-glycoprotein Expression and Pharmacoresistant Epilepsy: Cause or Consequence?
BACKGROUND Studies in rodent models of epilepsy suggest that multidrug efflux transporters at the blood-brain barrier, such as P-glycoprotein, might contribute to pharmacoresistance by reducing target-site concentrations of antiepileptic drugs. We assessed P-glycoprotein activity in vivo in patients with temporal lobe epilepsy. METHODS We selected 16 patients with pharmacoresistant temporal l...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2014
ISSN: 1535-7597,1535-7511
DOI: 10.5698/1535-7597-14.3.136